Anks4b, a novel target of HNF4α protein, interacts with GRP78 protein and regulates endoplasmic reticulum stress-induced apoptosis in pancreatic β-cells.

Sato Y, Hatta M, Karim MF, Sawa T, Wei FY, Sato S, Magnuson MA, Gonzalez FJ, Tomizawa K, Akaike T, Yoshizawa T, Yamagata K
J Biol Chem. 2012 287 (27): 23236-45

PMID: 22589549 · PMCID: PMC3391104 · DOI:10.1074/jbc.M112.368779

MeSH Terms (18)

Animals Apoptosis Carrier Proteins Cell Line, Tumor Diabetes Mellitus, Type 2 Endoplasmic Reticulum Endoplasmic Reticulum Stress Female Gene Expression Profiling Heat-Shock Proteins Insulin-Secreting Cells Insulinoma Intracellular Signaling Peptides and Proteins Mice Mice, Knockout Pancreatic Neoplasms Proteomics Transcriptional Activation

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