Preexisting MEK1 exon 3 mutations in V600E/KBRAF melanomas do not confer resistance to BRAF inhibitors.

Shi H, Moriceau G, Kong X, Koya RC, Nazarian R, Pupo GM, Bacchiocchi A, Dahlman KB, Chmielowski B, Sosman JA, Halaban R, Kefford RF, Long GV, Ribas A, Lo RS
Cancer Discov. 2012 2 (5): 414-24

PMID: 22588879 · PMCID: PMC3594852 · DOI:10.1158/2159-8290.CD-12-0022

MeSH Terms (20)

Adult Aged Antineoplastic Agents Cell Line, Tumor Drug Resistance, Neoplasm Exons Female HEK293 Cells Humans Imidazoles Indoles Male MAP Kinase Kinase 1 Melanoma Middle Aged Mutation Oximes Proto-Oncogene Proteins B-raf Sulfonamides Vemurafenib

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