Cooperative interactions of BRAFV600E kinase and CDKN2A locus deficiency in pediatric malignant astrocytoma as a basis for rational therapy.

Huillard E, Hashizume R, Phillips JJ, Griveau A, Ihrie RA, Aoki Y, Nicolaides T, Perry A, Waldman T, McMahon M, Weiss WA, Petritsch C, James CD, Rowitch DH
Proc Natl Acad Sci U S A. 2012 109 (22): 8710-5

PMID: 22586120 · PMCID: PMC3365162 · DOI:10.1073/pnas.1117255109

MeSH Terms (27)

Animals Apoptosis Astrocytoma Blotting, Western Cell Differentiation Cell Line, Tumor Cell Proliferation Cells, Cultured Child Cyclin-Dependent Kinase Inhibitor p16 Extracellular Signal-Regulated MAP Kinases Female Humans Immunohistochemistry Indoles Mice Mice, Inbred BALB C Mice, Knockout Mice, Nude Mice, SCID Neural Stem Cells Phosphorylation Piperazines Proto-Oncogene Proteins B-raf Pyridines Sulfonamides Xenograft Model Antitumor Assays

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