Mutation in cyclophilin B that causes hyperelastosis cutis in American Quarter Horse does not affect peptidylprolyl cis-trans isomerase activity but shows altered cyclophilin B-protein interactions and affects collagen folding.

Ishikawa Y, Vranka JA, Boudko SP, Pokidysheva E, Mizuno K, Zientek K, Keene DR, Rashmir-Raven AM, Nagata K, Winand NJ, B├Ąchinger HP
J Biol Chem. 2012 287 (26): 22253-65

PMID: 22556420 · PMCID: PMC3381186 · DOI:10.1074/jbc.M111.333336

MeSH Terms (19)

Animals Asthenia Circular Dichroism cis-trans-Isomerases Collagen Cyclophilins Endoplasmic Reticulum, Rough Horses Kinetics Mice Mice, Transgenic Molecular Chaperones Mutation Peptidylprolyl Isomerase Protein Binding Protein Folding Protein Structure, Tertiary Skin Diseases Surface Plasmon Resonance

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