The metabotropic glutamate receptor 8 agonist (S)-3,4-DCPG reverses motor deficits in prolonged but not acute models of Parkinson's disease.

Johnson KA, Jones CK, Tantawy MN, Bubser M, Marvanova M, Ansari MS, Baldwin RM, Conn PJ, Niswender CM
Neuropharmacology. 2013 66: 187-95

PMID: 22546615 · PMCID: PMC3432150 · DOI:10.1016/j.neuropharm.2012.03.029

MeSH Terms (23)

Aminobutyrates Animals Benzoates Catalepsy Disease Models, Animal Dopamine Dopamine D2 Receptor Antagonists Dose-Response Relationship, Drug Dyskinesia, Drug-Induced Excitatory Amino Acid Agonists Forelimb Glycine Haloperidol Injections, Intraventricular Male Neostriatum Parkinsonian Disorders Rats Rats, Sprague-Dawley Receptors, Dopamine D2 Receptors, Metabotropic Glutamate Reserpine Time Factors

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