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Unexpected extra-renal effects of loop diuretics in the preterm neonate.

Cotton R, Suarez S, Reese J
Acta Paediatr. 2012 101 (8): 835-45

PMID: 22536874 · PMCID: PMC3396710 · DOI:10.1111/j.1651-2227.2012.02699.x

UNLABELLED - The loop diuretics furosemide and bumetanide are commonly used in neonatal intensive care units (NICUs). Furosemide, because of its actions on the ubiquitous Na(+) -K(+) -2Cl(-) isoform cotransporter and its promotion of prostanoid production and release, also has non-diuretic effects on vascular smooth muscle, airways, the ductus arteriosus and theoretically the gastrointestinal tract. Loop diuretics also affect the central nervous system through modulation of the GABA-A chloride channel.

CONCLUSION -   The loop diuretics have a variety of biological effects that are potentially harmful as well as beneficial. Care should be taken with the use of these agents because the range of their effects may be broader than the single action sought by the prescribing physician.

© 2012 The Author(s)/Acta Paediatrica © 2012 Foundation Acta Paediatrica.

MeSH Terms (16)

Biomarkers Bronchopulmonary Dysplasia Bumetanide Central Nervous System Diuretics Ductus Arteriosus Furosemide gamma-Aminobutyric Acid Gastrointestinal Tract Humans Hyaline Membrane Disease Infant, Newborn Infant, Premature Intensive Care, Neonatal Lung Muscle, Smooth, Vascular

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