Mice expressing activated PI3K rapidly develop advanced colon cancer.

Leystra AA, Deming DA, Zahm CD, Farhoud M, Olson TJ, Hadac JN, Nettekoven LA, Albrecht DM, Clipson L, Sullivan R, Washington MK, Torrealba JR, Weichert JP, Halberg RB
Cancer Res. 2012 72 (12): 2931-6

PMID: 22525701 · PMCID: PMC3645915 · DOI:10.1158/0008-5472.CAN-11-4097

MeSH Terms (16)

Adenocarcinoma Animals Apoptosis Biomarkers, Tumor Cell Proliferation Cell Transformation, Neoplastic Colorectal Neoplasms Enzyme Activation Genotype Intestinal Mucosa Mice Mice, Inbred C57BL Mice, Transgenic Phosphatidylinositol 3-Kinases Proto-Oncogene Proteins c-akt Wnt Signaling Pathway

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