Intracellular transport of class II MHC molecules directed by invariant chain.

Lotteau V, Teyton L, Peleraux A, Nilsson T, Karlsson L, Schmid SL, Quaranta V, Peterson PA
Nature. 1990 348 (6302): 600-5

PMID: 2250716 · DOI:10.1038/348600a0

Three structural motifs in the invariant chain (li) control the intracellular transport of class II major histocompatibility complex molecules. An endoplasmic reticulum retention signal in the full-length li suggests a role for li in the alpha-beta heterodimer assembly. Another signal motif directs a truncated li, alone or associated with individual class II chains, to a degradation compartment by a pathway circumventing the Golgi. When this truncated li binds alpha-beta dimers, a third signal dominates, directing the complex by way of the Golgi to vesicles in the cell periphery, which may represent a subcompartment of recycling endosomes.

MeSH Terms (14)

Antibodies, Monoclonal Base Sequence Biological Transport Endoplasmic Reticulum Fluorescent Antibody Technique HeLa Cells Histocompatibility Antigens Class II Humans Macromolecular Substances Molecular Sequence Data Mutagenesis, Site-Directed Oligonucleotide Probes Signal Transduction Transfection

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