HPV prevalence and cervical intraepithelial neoplasia among HIV-infected women in Yunnan Province, China: a pilot study.

Zhang HY, Tiggelaar SM, Sahasrabuddhe VV, Smith JS, Jiang CQ, Mei RB, Wang XG, Li ZA, Qiao YL
Asian Pac J Cancer Prev. 2012 13 (1): 91-6

PMID: 22502720 · PMCID: PMC3809115 · DOI:10.7314/apjcp.2012.13.1.091

OBJECTIVES - To determine the prevalence of HPV and cervical neoplasia among HIV-infected women in southwestern China.

METHODS - Cervical cytology, HPV detection by Hybrid Capture-2™ assay, and diagnostic colposcopy were followed by cervical biopsy if indicated. Logistic regression analysis was used to analyze associations between HPV co-infection and cervical intraepithelial neoplasia (CIN), and HIV-related clinical and laboratory parameters.

RESULTS - Colposcopic-histopathologically proven CIN2+ lesions were present in 7/83 (8.4%) HIV-infected women. Nearly half (41/83, 43%) were co-infected with carcinogenic HPV genotypes. HPV co-infection was higher in women with colposcopic-histopathologically proven CIN2+ lesions than women with
CONCLUSIONS - HIV/AIDS care and treatment programs should integrate effective cervical cancer prevention services to mitigate the risk of invasive cervical cancer among HIV-infected women in China.

MeSH Terms (21)

Adult Aged Cervical Intraepithelial Neoplasia China Coinfection Colposcopy DNA, Viral Female HIV HIV Infections Humans Middle Aged Papillomaviridae Papillomavirus Infections Pilot Projects Polymerase Chain Reaction Prevalence Prognosis Uterine Cervical Neoplasms Vaginal Smears Young Adult

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