Kim-1/Tim-1 and immune cells: shifting sands.

Ichimura T, Brooks CR, Bonventre JV
Kidney Int. 2012 81 (9): 809-11

PMID: 22499138 · PMCID: PMC3339439 · DOI:10.1038/ki.2012.11

Kim-1/Tim-1 is an apoptotic-cell phagocytosis and scavenger receptor that is most highly upregulated in proximal tubular epithelium in acute and chronic kidney injury. While Kim-1/Tim-1 has been proposed to be a costimulatory molecule for immune cells, its potential immunological role has been controversial. In the presence of very high epithelial cell expression, understanding the influence of immune cell Kim-1/Tim-1 expression in kidney injury relies on a better definition of its functional significance in immune cells and better characterization of antibodies used to probe function.

MeSH Terms (9)

Animals CD4-Positive T-Lymphocytes Glomerulonephritis Hepatitis A Virus Cellular Receptor 1 Immunity, Cellular Kidney Lymphocyte Activation Male Membrane Proteins

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