Activation of invariant natural killer T cells by lipid excess promotes tissue inflammation, insulin resistance, and hepatic steatosis in obese mice.

Wu L, Parekh VV, Gabriel CL, Bracy DP, Marks-Shulman PA, Tamboli RA, Kim S, Mendez-Fernandez YV, Besra GS, Lomenick JP, Williams B, Wasserman DH, Van Kaer L
Proc Natl Acad Sci U S A. 2012 109 (19): E1143-52

PMID: 22493234 · PMCID: PMC3358828 · DOI:10.1073/pnas.1200498109

MeSH Terms (23)

Adipose Tissue, White Animals Antigens, CD1d CD8-Positive T-Lymphocytes Cells, Cultured Cytokines Dietary Fats Fatty Liver Female Flow Cytometry Galactosylceramides Inflammation Inflammation Mediators Insulin Resistance Lipids Lymphocyte Activation Macrophages Male Mice Mice, Inbred C57BL Mice, Knockout Natural Killer T-Cells Obesity

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