Exendin-4 decreases amphetamine-induced locomotor activity.

Erreger K, Davis AR, Poe AM, Greig NH, Stanwood GD, Galli A
Physiol Behav. 2012 106 (4): 574-8

PMID: 22465309 · PMCID: PMC3348974 · DOI:10.1016/j.physbeh.2012.03.014

Glucagon-like peptide-1 (GLP-1) is released in response to nutrient ingestion and is a regulator of energy metabolism and consummatory behaviors through both peripheral and central mechanisms. The GLP-1 receptor (GLP-1R) is widely distributed in the central nervous system, however little is known about how GLP-1Rs regulate ambulatory behavior. The abused psychostimulant amphetamine (AMPH) promotes behavioral locomotor activity primarily by inducing the release of the neurotransmitter dopamine. Here, we identify the GLP-1R agonist exendin-4 (Ex-4) as a modulator of behavioral activation by AMPH. We report that in rats a single acute administration of Ex-4 decreases both basal locomotor activity as well as AMPH-induced locomotor activity. Ex-4 did not induce behavioral responses reflecting anxiety or aversion. Our findings implicate GLP-1R signaling as a novel modulator of psychostimulant-induced behavior and therefore a potential therapeutic target for psychostimulant abuse.

Copyright © 2012 Elsevier Inc. All rights reserved.

MeSH Terms (17)

Amphetamine Animals Antimanic Agents Anxiety Central Nervous System Stimulants Conditioning, Operant Exenatide Glucagon-Like Peptide-1 Receptor Glucagon-Like Peptide 1 Lithium Chloride Male Motor Activity Peptides Rats Rats, Sprague-Dawley Receptors, Glucagon Venoms

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