The pan-ErbB negative regulator Lrig1 is an intestinal stem cell marker that functions as a tumor suppressor.

Powell AE, Wang Y, Li Y, Poulin EJ, Means AL, Washington MK, Higginbotham JN, Juchheim A, Prasad N, Levy SE, Guo Y, Shyr Y, Aronow BJ, Haigis KM, Franklin JL, Coffey RJ
Cell. 2012 149 (1): 146-58

PMID: 22464327 · PMCID: PMC3563328 · DOI:10.1016/j.cell.2012.02.042

MeSH Terms (16)

Adenoma Adenomatous Polyposis Coli Protein Animals Colon ErbB Receptors Gene Expression Profiling Genes, Tumor Suppressor Humans Intestinal Neoplasms Intestine, Small Membrane Glycoproteins Mice Nerve Tissue Proteins Receptors, G-Protein-Coupled Signal Transduction Stem Cells

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