Tyrosine-phosphorylated caveolin-1 (Tyr-14) increases sensitivity to paclitaxel by inhibiting BCL2 and BCLxL proteins via c-Jun N-terminal kinase (JNK).

Shajahan AN, Dobbin ZC, Hickman FE, Dakshanamurthy S, Clarke R
J Biol Chem. 2012 287 (21): 17682-17692

PMID: 22433870 · PMCID: PMC3366801 · DOI:10.1074/jbc.M111.304022

MeSH Terms (17)

Amino Acid Substitution Antineoplastic Agents, Phytogenic Apoptosis bcl-X Protein Breast Neoplasms Caveolin 1 Cell Line, Tumor Cell Survival Drug Resistance, Neoplasm Female Humans MAP Kinase Kinase 4 Mitochondria Mutation, Missense Paclitaxel Phosphorylation Protein Structure, Tertiary

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