Melanoma whole-exome sequencing identifies (V600E)B-RAF amplification-mediated acquired B-RAF inhibitor resistance.

Shi H, Moriceau G, Kong X, Lee MK, Lee H, Koya RC, Ng C, Chodon T, Scolyer RA, Dahlman KB, Sosman JA, Kefford RF, Long GV, Nelson SF, Ribas A, Lo RS
Nat Commun. 2012 3: 724

PMID: 22395615 · PMCID: PMC3530385 · DOI:10.1038/ncomms1727

MeSH Terms (24)

Adult Aged Antineoplastic Agents Base Sequence Benzimidazoles Cell Line Cell Line, Tumor DNA Copy Number Variations Drug Resistance, Neoplasm Exome Extracellular Signal-Regulated MAP Kinases Female Gene Amplification HEK293 Cells Humans Indoles Male MAP Kinase Kinase 1 Melanoma Middle Aged Proto-Oncogene Proteins B-raf Sequence Analysis, DNA Sulfonamides Vemurafenib

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