A.S.P.E.N. position paper: Clinical role for alternative intravenous fat emulsions.

Vanek VW, Seidner DL, Allen P, Bistrian B, Collier S, Gura K, Miles JM, Valentine CJ, Kochevar M, Novel Nutrient Task Force, Intravenous Fat Emulsions Workgroup, American Society for Parenteral and Enteral Nutrition (A.S.P.E.N.) Board of Directors
Nutr Clin Pract. 2012 27 (2): 150-92

PMID: 22378798 · DOI:10.1177/0884533612439896

The currently available, standard soybean oil (SO)-based intravenous fat emulsions (IVFEs) meet the needs of most parenteral nutrition (PN) patients. There are alternative oil-based fat emulsions, such as medium-chain triglycerides (MCTs), olive oils (OOs), and fish oils (FOs), that, based on extensive usage in Europe, have an equivalent safety profile to SO. These alternative IVFEs are metabolized via different pathways, which may lead to less proinflammatory effects and less immune suppression. These alternative oil-based IVFEs are not currently available in the United States. Many patients who require IVFEs are already in a compromised state. Such patients could potentially have better clinical outcomes when receiving one of the alternative IVFEs to diminish the intake of the potentially proinflammatory ω-6 fatty acid-linoleic acid-which comprises more than 50% of the fatty acid profile in SO. Further research is needed on these alternative oil-based IVFEs to identify which IVFE oils or which combination of oils may be most clinically useful for specific patient populations.

MeSH Terms (15)

Europe Fat Emulsions, Intravenous Fish Oils Humans Immunity Inflammation Linoleic Acid Lipids Olive Oil Parenteral Nutrition Plant Oils Societies, Medical Soybean Oil Triglycerides United States

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