PASADENA hyperpolarized 13C phospholactate.

Shchepin RV, Coffey AM, Waddell KW, Chekmenev EY
J Am Chem Soc. 2012 134 (9): 3957-60

PMID: 22352377 · PMCID: PMC3318994 · DOI:10.1021/ja210639c

We demonstrate that potassium 1-(13)C-phosphoenolpyruvate becomes hyperpolarized potassium 1-(13)C-phospholactate with (13)C T(1) = 36 s after molecular hydrogenation by PASADENA (Parahydrogen and Synthesis Allows Dramatically Enhanced Nuclear Alignment). This proof-of-principle study was conducted with a fully protonated molecular precursor. (13)C was polarized to a level of 1%, corresponding to nearly 4000-fold sensitivity enhancement at 3 T. The relevant homo- and heteronuclear spin-spin couplings are reported.

© 2012 American Chemical Society

MeSH Terms (6)

Carbon Isotopes Lactates Magnetic Resonance Spectroscopy Molecular Structure Potassium Reference Standards

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