DNA cleavage and opening reactions of human topoisomerase IIα are regulated via Mg2+-mediated dynamic bending of gate-DNA.

Lee S, Jung SR, Heo K, Byl JA, Deweese JE, Osheroff N, Hohng S
Proc Natl Acad Sci U S A. 2012 109 (8): 2925-30

PMID: 22323612 · PMCID: PMC3286967 · DOI:10.1073/pnas.1115704109

MeSH Terms (13)

Amino Acids, Acidic Antigens, Neoplasm Base Sequence Cations, Divalent DNA DNA-Binding Proteins DNA Breaks, Double-Stranded DNA Cleavage DNA Topoisomerases, Type II Humans Magnesium Molecular Sequence Data Nucleic Acid Conformation

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