Amsacrine as a topoisomerase II poison: importance of drug-DNA interactions.

Ketron AC, Denny WA, Graves DE, Osheroff N
Biochemistry. 2012 51 (8): 1730-9

PMID: 22304499 · PMCID: PMC3289736 · DOI:10.1021/bi201159b

MeSH Terms (14)

Amsacrine Antigens, Neoplasm Antineoplastic Agents Binding Sites DNA DNA-Binding Proteins DNA Cleavage DNA Topoisomerases, Type II Humans Intercalating Agents Kinetics Molecular Dynamics Simulation Structure-Activity Relationship Topoisomerase II Inhibitors

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