Leukemia inhibitory factor: a paracrine mediator of bone metabolism.

Sims NA, Johnson RW
Growth Factors. 2012 30 (2): 76-87

PMID: 22304408 · DOI:10.3109/08977194.2012.656760

Leukemia inhibitory factor (LIF) is a soluble interleukin-6 family cytokine that regulates a number of physiologic functions, including normal skeletal remodeling. LIF signals through the cytokine co-receptor glycoprotein-130 in complex with its cytokine-specific receptor [LIF receptor (LIFR)] to activate signaling cascades in cells of the skeletal system, including stromal cells, chondrocytes, osteoblasts, osteocytes, adipocytes, and synovial fibroblasts. LIF action on skeletal cells is cell-type specific, and frequently dependent on the state of cell differentiation. This review describes the expression patterns of LIF and LIFR in bone, their regulation by physiological and inflammatory agents, as well as cell-specific influences of LIF on osteoblast, osteoclast, chondrocyte, and adipocyte differentiation. The actions of LIF in normal skeletal growth and maintenance, in pathological states (e.g. autocrine tumor cell signaling and growth in bone) and inflammatory conditions (e.g. arthritis) will be discussed, as well as the signaling pathways activated by LIF and their importance in bone formation and resorption.

MeSH Terms (13)

Animals Bone and Bones Bone Diseases Chondrocytes Cytokine Receptor gp130 Gene Expression Regulation Humans Inflammation Leukemia Inhibitory Factor Leukemia Inhibitory Factor Receptor alpha Subunit Mice Osteoblasts Osteogenesis

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