Consolidative therapy with stem cell transplantation improves survival of patients with mantle cell lymphoma after any induction regimen.

Reddy N, Greer JP, Goodman S, Kassim A, Morgan DS, Chinratanalab W, Brandt S, Englehardt B, Oluwole O, Jagasia MH, Savani BN
Exp Hematol. 2012 40 (5): 359-66

PMID: 22269117 · PMCID: PMC4845757 · DOI:10.1016/j.exphem.2012.01.012

Intensive induction regimen followed by high-dose chemotherapy and autologous stem cell transplantation (auto-SCT) is frequently used to improve outcomes in patients with mantle-cell lymphoma. The comparative impact of conventional vs intensive induction regimen before transplantation is unknown. Forty-eight patients with mantle-cell lymphoma receiving SCT at our institution between January 2000 and December 2010 were included in this study. At the time of initial presentation, 43 (89.5%) had stage IV disease and 18 (37.5%) received more than one chemotherapy regimen before transplantation. Forty patients underwent auto-SCT and 7 had allogeneic SCT (allo-SCT); 1 patient had an allo-SCT for relapsed disease after auto-SCT. At the time of this analysis (median follow-up of 6 years from diagnosis and 4 years from transplantation), 40 patients (88%) were alive with a 5-year disease-free survival of 74.8%. Age, disease stage, number of regimens pre-SCT, pre-SCT disease status, and type of SCT had no impact on long-term outcomes. Importantly, there were no differences among the types of induction regimen on outcomes in this cohort receiving SCT. Based on our data, we believe that future studies should focus on strategies to prevent disease relapse rather than comparing induction regimens before stem cell transplantation.

Copyright © 2012 ISEH - Society for Hematology and Stem Cells. All rights reserved.

MeSH Terms (28)

Adult Aged Antibodies, Monoclonal, Murine-Derived Antineoplastic Combined Chemotherapy Protocols Boronic Acids Bortezomib Consolidation Chemotherapy Cyclophosphamide Dexamethasone Disease-Free Survival Doxorubicin Female Humans Kaplan-Meier Estimate Lymphoma, Mantle-Cell Male Middle Aged Peripheral Blood Stem Cell Transplantation Prednisone Pyrazines Remission Induction Retrospective Studies Rituximab Transplantation, Autologous Transplantation, Homologous Transplantation Conditioning Treatment Outcome Vincristine

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