In vivo formation of dihydroxylated and glutathione conjugate metabolites derived from thalidomide and 5-Hydroxythalidomide in humanized TK-NOG mice.

Yamazaki H, Suemizu H, Shimizu M, Igaya S, Shibata N, Nakamura M, Chowdhury G, Guengerich FP
Chem Res Toxicol. 2012 25 (2): 274-6

PMID: 22268628 · PMCID: PMC3976424 · DOI:10.1021/tx300009j

MeSH Terms (9)

Animals Chimera Glutathione Hepatocytes Humans Hydroxylation Mice Teratogens Thalidomide

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