Discovery of 2-(2-benzoxazoyl amino)-4-aryl-5-cyanopyrimidine as negative allosteric modulators (NAMs) of metabotropic glutamate receptor 5 (mGlu₅): from an artificial neural network virtual screen to an in vivo tool compound.

Mueller R, Dawson ES, Meiler J, Rodriguez AL, Chauder BA, Bates BS, Felts AS, Lamb JP, Menon UN, Jadhav SB, Kane AS, Jones CK, Gregory KJ, Niswender CM, Conn PJ, Olsen CM, Winder DG, Emmitte KA, Lindsley CW
ChemMedChem. 2012 7 (3): 406-14

PMID: 22267125 · PMCID: PMC3517057 · DOI:10.1002/cmdc.201100510

MeSH Terms (21)

Allosteric Regulation Animals Anxiety Disorders Behavior, Animal Benzoxazoles Brain Drug Discovery Glutamic Acid HEK293 Cells High-Throughput Screening Assays Humans Injections, Intraperitoneal Mice Mice, Inbred C57BL Neural Networks (Computer) Psychotropic Drugs Pyrimidines Receptor, Metabotropic Glutamate 5 Receptors, Metabotropic Glutamate ROC Curve Small Molecule Libraries

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