Cyclooxygenase-1-selective inhibitors based on the (E)-2'-des-methyl-sulindac sulfide scaffold.

Liedtke AJ, Crews BC, Daniel CM, Blobaum AL, Kingsley PJ, Ghebreselasie K, Marnett LJ
J Med Chem. 2012 55 (5): 2287-300

PMID: 22263894 · PMCID: PMC3297362 · DOI:10.1021/jm201528b

MeSH Terms (16)

Animals Antineoplastic Agents Cell Line, Tumor Cell Proliferation Cyclooxygenase 1 Cyclooxygenase 2 Inhibitors Cyclooxygenase Inhibitors Drug Screening Assays, Antitumor Female Humans Hydrophobic and Hydrophilic Interactions Mice Sheep Stereoisomerism Structure-Activity Relationship Sulindac

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