CD4+ cell count and HIV load as predictors of size of anal warts over time in HIV-infected women.

Luu HN, Amirian ES, Chan W, Beasley RP, Piller LB, Scheurer ME
J Infect Dis. 2012 205 (4): 578-85

PMID: 22246682 · PMCID: PMC3266135 · DOI:10.1093/infdis/jir813

BACKGROUND - Little is known about the associations between CD4(+) cell counts, human immunodeficiency virus (HIV) load, and human papillomavirus "low-risk" types in noncancerous clinical outcomes. This study examined whether CD4(+) count and HIV load predict the size of the largest anal warts in 976 HIV-infected women in an ongoing cohort.

METHODS - A linear mixed model was used to determine the association between size of anal wart and CD4(+) count and HIV load.

RESULTS - The incidence of anal warts was 4.15 cases per 100 person-years (95% confidence interval [CI], 3.83-4.77) and 1.30 cases per 100 person-years (95% CI, 1.00-1.58) in HIV-infected and HIV-uninfected women, respectively. There appeared to be an inverse association between size of the largest anal warts and CD4(+) count at baseline; however, this was not statistically significant. There was no association between size of the largest anal warts and CD4(+) count or HIV load over time.

CONCLUSIONS - There was no evidence for an association between size of the largest anal warts and CD4(+) count or HIV load over time. Further exploration on the role of immune response on the development of anal warts is warranted in a larger study.

MeSH Terms (10)

Adult Anal Canal CD4 Lymphocyte Count Female HIV Infections Humans Incidence Middle Aged Viral Load Warts

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