AgRP and POMC neurons are hypophysiotropic and coordinately regulate multiple endocrine axes in a larval teleost.

Zhang C, Forlano PM, Cone RD
Cell Metab. 2012 15 (2): 256-64

PMID: 22245570 · PMCID: PMC3332529 · DOI:10.1016/j.cmet.2011.12.014

Plasticity in growth and reproductive behavior is found in many vertebrate species, but is common in male teleost fish. Typically, "bourgeois" males are considerably larger and defend breeding territories while "parasitic" variants are small and use opportunistic breeding strategies. The P locus mediates this phenotypic variation in Xiphophorus and encodes variant alleles of the melanocortin-4 receptor (MC4R). However, deletion of the MC4R has modest effects on somatic growth and reproduction in mammals, suggesting a fundamental difference in the neuroendocrine function of central melanocortin signaling in teleosts. Here we show in a teleost that the hypothalamic pro-opiomelanocortin and AgRP neurons are hypophysiotropic, projecting to the pituitary to coordinately regulate multiple pituitary hormones. Indeed, AgRP-mediated suppression of MC4R appears essential for early larval growth. This identifies the mechanism by which the central melanocortin system coordinately regulates growth and reproduction in teleosts and suggests it is an important anatomical substrate for evolutionary adaptation.

Copyright © 2012 Elsevier Inc. All rights reserved.

MeSH Terms (17)

Agouti-Related Protein Analysis of Variance Animals Body Weights and Measures Hypothalamus Immunohistochemistry In Situ Hybridization Larva Male Neurons Oligonucleotides Pituitary Hormones Pro-Opiomelanocortin Real-Time Polymerase Chain Reaction Receptor, Melanocortin, Type 4 Signal Transduction Zebrafish

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