Insights from crystal structures into the opposite effects on RNA affinity caused by the S- and R-6'-methyl backbone modifications of 3'-fluoro hexitol nucleic acid.

Pallan PS, Yu J, Allerson CR, Swayze EE, Seth P, Egli M
Biochemistry. 2012 51 (1): 7-9

PMID: 22229409 · PMCID: PMC3257178 · DOI:10.1021/bi201810r

MeSH Terms (10)

Crystallography, X-Ray Hexosediphosphates Nucleic Acid Conformation Nucleic Acid Heteroduplexes Oligonucleotides, Antisense RNA Stereoisomerism Structure-Activity Relationship Sugar Alcohols Thermodynamics

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