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Humanized mice for the study of type 1 and type 2 diabetes.

Greiner DL, Brehm MA, Hosur V, Harlan DM, Powers AC, Shultz LD
Ann N Y Acad Sci. 2011 1245: 55-8

PMID: 22211980 · PMCID: PMC3384500 · DOI:10.1111/j.1749-6632.2011.06318.x

The availability of immunodeficient mice engrafted with functional human immune systems and islets permits in vivo study of human diabetes without putting patients at risk.

© 2011 New York Academy of Sciences.

MeSH Terms (15)

Animals Diabetes Mellitus, Type 1 Diabetes Mellitus, Type 2 Disease Models, Animal Hematopoietic Stem Cell Transplantation HLA Antigens Humans Hyperglycemia Interleukin Receptor Common gamma Subunit Islets of Langerhans Transplantation Mice Mice, Inbred NOD Mice, SCID Mice, Transgenic Transplantation, Heterologous

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