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Cell-associated hemolysis induced by Helicobacter pylori is mediated by phospholipases with mitogen-activated protein kinase-activating properties.

Sitaraman R, Israel DA, Romero-Gallo J, Peek RM
J Clin Microbiol. 2012 50 (3): 1014-8

PMID: 22205825 · PMCID: PMC3295145 · DOI:10.1128/JCM.05252-11

Pathogenic Helicobacter pylori strains can selectively activate epithelial mitogen-activated protein kinase (MAPK) signaling pathways linked with disease. We now demonstrate that H. pylori-induced hemolysis is strain specific and is mediated by phospholipases PldA1 and PldD. Inactivation of PldD inhibited activation of extracellular signal-regulated kinases 1 and 2 (ERK1/2), indicating that H. pylori hemolytic phospholipases also harbor MAPK-activating properties.

MeSH Terms (8)

Bacterial Adhesion Erythrocytes Gene Deletion Helicobacter pylori Hemolysis Humans Mitogen-Activated Protein Kinases Phospholipases

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