Polymorphisms in transcobalamin II gene is associated with coronary artery disease in Indian population.

Garg G, Kumar J, Tanwar VS, Basak T, Seth S, Karthikeyan G, Sengupta S
Biomarkers. 2012 17 (2): 119-24

PMID: 22188304 · DOI:10.3109/1354750X.2011.642408

Transcobalamin (TCII) is a key enzyme involved in intracellular transport of vitamin B12. We had earlier shown that vitamin B12 levels are associated with Coronary Artery Disease (CAD). Herein, we evaluated the association of four nonsynonymous single nucleotide polymorphisms (SNPs) of TCII gene with CAD in 1398 individuals (589 CAD cases and 809 controls). Using logistic regression, we found that three SNPs (G1196A, C776G and C1043T) were significantly associated with CAD and one (G1196A) with vitamin B12 levels even after controlling for confounding factors. Thus, polymorphisms in TCII gene may play an important role in the etiology of CAD.

MeSH Terms (16)

Adult Alleles Case-Control Studies Coronary Artery Disease European Continental Ancestry Group Female Gene Frequency Genotype Humans India Male Middle Aged Polymorphism, Single Nucleotide Regression Analysis Transcobalamins Vitamin B 12

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