Synthesis and pharmacological characterization of a novel sigma receptor ligand with improved metabolic stability and antagonistic effects against methamphetamine.

Seminerio MJ, Robson MJ, Abdelazeem AH, Mesangeau C, Jamalapuram S, Avery BA, McCurdy CR, Matsumoto RR
AAPS J. 2012 14 (1): 43-51

PMID: 22183188 · PMCID: PMC3291180 · DOI:10.1208/s12248-011-9311-8

MeSH Terms (19)

Administration, Oral Animals Behavior, Animal Benzothiazoles Binding Sites Central Nervous System Stimulants Dose-Response Relationship, Drug Half-Life Injections, Intraperitoneal Ligands Male Methamphetamine Mice Motor Activity Piperazines Protein Binding Radioligand Assay Receptors, sigma Sulfur Compounds

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