Allosteric modulation of seven transmembrane spanning receptors: theory, practice, and opportunities for central nervous system drug discovery.

Melancon BJ, Hopkins CR, Wood MR, Emmitte KA, Niswender CM, Christopoulos A, Conn PJ, Lindsley CW
J Med Chem. 2012 55 (4): 1445-64

PMID: 22148748 · PMCID: PMC3349997 · DOI:10.1021/jm201139r

MeSH Terms (10)

Allosteric Regulation Animals Central Nervous System Agents Drug Discovery Humans Ligands Receptors, G-Protein-Coupled Receptors, Metabotropic Glutamate Receptors, Muscarinic Structure-Activity Relationship

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