RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E).

Poulikakos PI, Persaud Y, Janakiraman M, Kong X, Ng C, Moriceau G, Shi H, Atefi M, Titz B, Gabay MT, Salton M, Dahlman KB, Tadi M, Wargo JA, Flaherty KT, Kelley MC, Misteli T, Chapman PB, Sosman JA, Graeber TG, Ribas A, Lo RS, Rosen N, Solit DB
Nature. 2011 480 (7377): 387-90

PMID: 22113612 · PMCID: PMC3266695 · DOI:10.1038/nature10662

MeSH Terms (18)

Alternative Splicing Animals Cell Line, Tumor Drug Resistance, Neoplasm Exons Extracellular Signal-Regulated MAP Kinases Humans Indoles MAP Kinase Signaling System Melanoma Mice Mutant Proteins Protein Isoforms Protein Kinase Inhibitors Protein Multimerization Proto-Oncogene Proteins B-raf Sulfonamides Vemurafenib

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