Pharmacological suppression of hepcidin increases macrophage cholesterol efflux and reduces foam cell formation and atherosclerosis.

Saeed O, Otsuka F, Polavarapu R, Karmali V, Weiss D, Davis T, Rostad B, Pachura K, Adams L, Elliott J, Taylor WR, Narula J, Kolodgie F, Virmani R, Hong CC, Finn AV
Arterioscler Thromb Vasc Biol. 2012 32 (2): 299-307

PMID: 22095982 · PMCID: PMC3262074 · DOI:10.1161/ATVBAHA.111.240101

MeSH Terms (23)

Animals Antimicrobial Cationic Peptides Apolipoproteins E Atherosclerosis ATP-Binding Cassette Transporters ATP Binding Cassette Transporter, Subfamily G, Member 1 ATP Binding Cassette Transporter 1 Bone Morphogenetic Proteins Cell Differentiation Cholesterol Disease Models, Animal Foam Cells Hepcidins Iron Lipoproteins Macrophages Male Mice Mice, Inbred C57BL Mice, Knockout Pyrazoles Pyrimidines Signal Transduction

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