Endoplasmic reticulum stress decreases intracellular thyroid hormone activation via an eIF2a-mediated decrease in type 2 deiodinase synthesis.

Arrojo E Drigo R, Fonseca TL, Castillo M, Salathe M, Simovic G, Mohácsik P, Gereben B, Bianco AC
Mol Endocrinol. 2011 25 (12): 2065-75

PMID: 22053000 · PMCID: PMC3231828 · DOI:10.1210/me.2011-1061

MeSH Terms (21)

Animals Cell Line Cystic Fibrosis Down-Regulation Endoplasmic Reticulum Stress Epithelial Cells Eukaryotic Initiation Factor-2 Gene Expression Humans Iodide Peroxidase Mice Proteasome Endopeptidase Complex Protein Stability Proteolysis Respiratory Mucosa Signal Transduction Thapsigargin Thyroxine Transcription Factor CHOP Triiodothyronine Tunicamycin

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