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Pyridoxine-derived bicyclic aminopyridinol antioxidants: synthesis and their antioxidant activities.

Nam TG, Ku JM, Rector CL, Choi H, Porter NA, Jeong BS
Org Biomol Chem. 2011 9 (24): 8475-82

PMID: 22042081 · DOI:10.1039/c1ob05144j

A few facile synthetic pathways for bicyclic aminopyridinol antioxidants are presented. Attachment of a long alkyl chain to the bicyclic pyridinol scaffold was established using ester linkage. Non-substituted pyrrolopyridinols and 1,3-oxazine-fused pyridinols were also synthesized as novel antioxidant scaffolds. Antioxidant activities were measured by a radical clock method and new compounds prepared are comparable to the best bicyclic aminopyridinol antioxidants.

MeSH Terms (5)

Aminopyridines Antioxidants Bridged Bicyclo Compounds, Heterocyclic Molecular Structure Pyridoxine

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