Pyridoxine-derived bicyclic aminopyridinol antioxidants: synthesis and their antioxidant activities.

Nam TG, Ku JM, Rector CL, Choi H, Porter NA, Jeong BS
Org Biomol Chem. 2011 9 (24): 8475-82

PMID: 22042081 · DOI:10.1039/c1ob05144j

A few facile synthetic pathways for bicyclic aminopyridinol antioxidants are presented. Attachment of a long alkyl chain to the bicyclic pyridinol scaffold was established using ester linkage. Non-substituted pyrrolopyridinols and 1,3-oxazine-fused pyridinols were also synthesized as novel antioxidant scaffolds. Antioxidant activities were measured by a radical clock method and new compounds prepared are comparable to the best bicyclic aminopyridinol antioxidants.

MeSH Terms (5)

Aminopyridines Antioxidants Bridged Bicyclo Compounds, Heterocyclic Molecular Structure Pyridoxine

Connections (1)

This publication is referenced by other Labnodes entities: