Plasma biomarkers of oxidative stress and genetic variants in age-related macular degeneration.

Brantley MA, Osborn MP, Sanders BJ, Rezaei KA, Lu P, Li C, Milne GL, Cai J, Sternberg P
Am J Ophthalmol. 2012 153 (3): 460-467.e1

PMID: 22035603 · PMCID: PMC3288635 · DOI:10.1016/j.ajo.2011.08.033

PURPOSE - To compare plasma levels of oxidative stress biomarkers in patients with age-related macular degeneration (AMD) and controls and to evaluate a potential relationship between biochemical markers of oxidative stress and AMD susceptibility genotypes.

DESIGN - Prospective case-control study.

METHODS - Plasma levels of oxidative stress biomarkers were determined in 77 AMD patients and 75 controls recruited from a clinical practice. Cysteine, cystine (CySS), glutathione, isoprostane, and isofuran were measured, and participants were genotyped for polymorphisms in the complement factor H (CFH) and age-related maculopathy susceptibility 2 (ARMS2) genes.

RESULTS - CySS was elevated in cases compared with controls (P = .013). After adjustment for age, sex, and smoking, this association was not significant. In all participants, CySS levels were associated with the CFH polymorphism rs3753394 (P = .028) as well as an 8-allele CFH haplotype (P = .029) after correction for age, gender, and smoking. None of the other plasma markers was related to AMD status in our cohort.

CONCLUSIONS - Our investigation of the gene-environment interaction involved in AMD revealed a relationship between a plasma biomarker of oxidative stress, CySS, and CFH genotype. These data suggest a potential association between inflammatory regulators and redox status in AMD pathogenesis.

Copyright © 2012 Elsevier Inc. All rights reserved.

MeSH Terms (22)

Aged Biomarkers Case-Control Studies Chromatography, High Pressure Liquid Complement Factor H Cysteine Cystine Female Furans Genetic Predisposition to Disease Genetic Variation Genotype Glutathione Humans Isoprostanes Lipid Peroxidation Macular Degeneration Male Oxidative Stress Polymorphism, Single Nucleotide Prospective Studies Proteins

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