Berberine protects against high fat diet-induced dysfunction in muscle mitochondria by inducing SIRT1-dependent mitochondrial biogenesis.

Gomes AP, Duarte FV, Nunes P, Hubbard BP, Teodoro JS, Varela AT, Jones JG, Sinclair DA, Palmeira CM, Rolo AP
Biochim Biophys Acta. 2012 1822 (2): 185-95

PMID: 22027215 · PMCID: PMC3366688 · DOI:10.1016/j.bbadis.2011.10.008

MeSH Terms (22)

AMP-Activated Protein Kinases Animals Berberine Cell Line Diet, High-Fat Glucose Hormones Hyperglycemia Insulin Resistance Male Mice Mitochondria Mitochondria, Muscle Muscle, Skeletal Myoblasts NAD Obesity Organelle Biogenesis Phosphorylation Rats Rats, Sprague-Dawley Sirtuin 1

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