Duration of treatment in postmenopausal osteoporosis: how long to treat and what are the consequences of cessation of treatment?

Laster AJ, Tanner SB
Rheum Dis Clin North Am. 2011 37 (3): 323-36, v

PMID: 22023894 · DOI:10.1016/j.rdc.2011.07.007

Although a variety of medications are effective for the treatment of postmenopausal osteoporosis, there is concern that long-term use may incur side effects. Consequently, some have proposed discontinuing or temporarily suspending treatment after a defined period of time. As the benefits of fracture risk reduction may recede during this "drug holiday", the clinician may be faced with deciding when to resume therapy (and with which agent) while avoiding the possible cumulative risk of side effects. This article summarizes data regarding length of treatment and the effects of cessation of treatment on bone density, bone turnover markers, and fracture risk.

Copyright © 2011 Elsevier Inc. All rights reserved.

MeSH Terms (11)

Bone and Bones Bone Density Conservation Agents Estrogen Replacement Therapy Female Fractures, Bone Humans Middle Aged Osteoporosis, Postmenopausal Practice Guidelines as Topic Risk Factors Substance Withdrawal Syndrome

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