Discovery, synthesis, and structure-activity relationship development of a series of N-4-(2,5-dioxopyrrolidin-1-yl)phenylpicolinamides (VU0400195, ML182): characterization of a novel positive allosteric modulator of the metabotropic glutamate receptor 4 (mGlu(4)) with oral efficacy in an antiparkinsonian animal model.

Jones CK, Engers DW, Thompson AD, Field JR, Blobaum AL, Lindsley SR, Zhou Y, Gogliotti RD, Jadhav S, Zamorano R, Bogenpohl J, Smith Y, Morrison R, Daniels JS, Weaver CD, Conn PJ, Lindsley CW, Niswender CM, Hopkins CR
J Med Chem. 2011 54 (21): 7639-47

PMID: 21966889 · PMCID: PMC3226828 · DOI:10.1021/jm200956q

MeSH Terms (18)

Administration, Oral Allosteric Regulation Animals Antiparkinson Agents Biological Availability Catalepsy CHO Cells Cricetinae Cricetulus Haloperidol Humans In Vitro Techniques Isoindoles Microsomes, Liver Picolinic Acids Rats Receptors, Metabotropic Glutamate Structure-Activity Relationship

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