Mucosal memory CD8⁺ T cells are selected in the periphery by an MHC class I molecule.

Huang Y, Park Y, Wang-Zhu Y, Larange A, Arens R, Bernardo I, Olivares-Villagómez D, Herndler-Brandstetter D, Abraham N, Grubeck-Loebenstein B, Schoenberger SP, Van Kaer L, Kronenberg M, Teitell MA, Cheroutre H
Nat Immunol. 2011 12 (11): 1086-95

PMID: 21964609 · PMCID: PMC3197978 · DOI:10.1038/ni.2106

The presence of immune memory at pathogen-entry sites is a prerequisite for protection. Nevertheless, the mechanisms that warrant immunity at peripheral interfaces are not understood. Here we show that the nonclassical major histocompatibility complex (MHC) class I molecule thymus leukemia antigen (TL), induced on dendritic cells interacting with CD8αα on activated CD8αβ(+) T cells, mediated affinity-based selection of memory precursor cells. Furthermore, constitutive expression of TL on epithelial cells led to continued selection of mature CD8αβ(+) memory T cells. The memory process driven by TL and CD8αα was essential for the generation of CD8αβ(+) memory T cells in the intestine and the accumulation of highly antigen-sensitive CD8αβ(+) memory T cells that form the first line of defense at the largest entry port for pathogens.

MeSH Terms (17)

Animals Antigens CD8 Antigens Cell Differentiation Clonal Selection, Antigen-Mediated Dendritic Cells Immunity, Mucosal Immunologic Memory Listeriosis Lymphocyte Activation Membrane Glycoproteins Mice Mice, Inbred C57BL Mice, Transgenic Precursor Cells, T-Lymphoid T-Lymphocytes Transgenes

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