A common 5'-UTR variant in MATE2-K is associated with poor response to metformin.

Choi JH, Yee SW, Ramirez AH, Morrissey KM, Jang GH, Joski PJ, Mefford JA, Hesselson SE, Schlessinger A, Jenkins G, Castro RA, Johns SJ, Stryke D, Sali A, Ferrin TE, Witte JS, Kwok PY, Roden DM, Wilke RA, McCarty CA, Davis RL, Giacomini KM
Clin Pharmacol Ther. 2011 90 (5): 674-84

PMID: 21956618 · PMCID: PMC3329222 · DOI:10.1038/clpt.2011.165

MeSH Terms (25)

Adult Aged Alleles Animals Diabetes Mellitus, Type 2 Female Genetic Variation Glycated Hemoglobin A Haplotypes HCT116 Cells HEK293 Cells Humans Hypoglycemic Agents LLC-PK1 Cells Luciferases Male Metformin Middle Aged Organic Cation Transport Proteins Polymorphism, Genetic Promoter Regions, Genetic Racial Groups Retrospective Studies Swine Treatment Outcome

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