A mass-selective variable-temperature drift tube ion mobility-mass spectrometer for temperature dependent ion mobility studies.

May JC, Russell DH
J Am Soc Mass Spectrom. 2011 22 (7): 1134-45

PMID: 21953095 · DOI:10.1007/s13361-011-0148-2

A hybrid ion mobility-mass spectrometer (IM-MS) incorporating a variable-temperature (80-400 K) drift tube is presented. The instrument utilizes an electron ionization (EI) source for fundamental small molecule studies. Ions are transferred to the IM-MS analyzer stages through a quadrupole, which can operate in either broad transmission or mass-selective mode. Ion beam modulation for the ion mobility experiment is accomplished by an electronic shutter gate. The variable-temperature ion mobility spectrometer consists of a 30.2 cm uniform field drift tube enclosed within a thermal envelope. Subambient temperatures down to 80 K are achievable through cryogenic cooling with liquid nitrogen, while elevated temperatures can be accessed through resistive heating of the envelope. Mobility separated ions are mass analyzed by an orthogonal time-of-flight (TOF) mass spectrometer. This report describes the technological considerations for operating the instrument at variable temperature, and preliminary results are presented for IM-MS analysis of several small mass ions. Specifically, mobility separations of benzene fragment ions generated by EI are used to illustrate significantly improved (greater than 50%) ion mobility resolution at low temperatures resulting from decreased diffusional broadening. Preliminary results on the separation of long-lived electronic states of Ti(+) formed by EI of TiCl(4) and hydration reactions of Ti(+) with residual water are presented.

MeSH Terms (9)

Benzene Chlorides Cold Temperature Equipment Design Ions Krypton Mass Spectrometry Nitrogen Titanium

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