Development of a highly selective, orally bioavailable and CNS penetrant M1 agonist derived from the MLPCN probe ML071.

Lebois EP, Digby GJ, Sheffler DJ, Melancon BJ, Tarr JC, Cho HP, Miller NR, Morrison R, Bridges TM, Xiang Z, Daniels JS, Wood MR, Conn PJ, Lindsley CW
Bioorg Med Chem Lett. 2011 21 (21): 6451-5

PMID: 21930376 · PMCID: PMC3190051 · DOI:10.1016/j.bmcl.2011.08.084

MeSH Terms (10)

Administration, Oral Animals Biological Availability Cell Line Central Nervous System Humans Muscarinic Agonists Rats Receptor, Muscarinic M1 Structure-Activity Relationship

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