Inhibiting Cxcr2 disrupts tumor-stromal interactions and improves survival in a mouse model of pancreatic ductal adenocarcinoma.

Ijichi H, Chytil A, Gorska AE, Aakre ME, Bierie B, Tada M, Mohri D, Miyabayashi K, Asaoka Y, Maeda S, Ikenoue T, Tateishi K, Wright CV, Koike K, Omata M, Moses HL
J Clin Invest. 2011 121 (10): 4106-17

PMID: 21926469 · PMCID: PMC3195452 · DOI:10.1172/JCI42754

MeSH Terms (20)

Animals Carcinoma, Pancreatic Ductal Chemokines, CXC Connective Tissue Growth Factor Female Gene Expression Humans Mice Mice, Inbred C57BL Mice, Knockout Mice, Nude Pancreatic Neoplasms Protein Serine-Threonine Kinases Proto-Oncogene Proteins p21(ras) Receptor, Transforming Growth Factor-beta Type II Receptors, Interleukin-8B Receptors, Transforming Growth Factor beta Signal Transduction Stromal Cells Tumor Microenvironment

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