Synthesis, improved antisense activity and structural rationale for the divergent RNA affinities of 3'-fluoro hexitol nucleic acid (FHNA and Ara-FHNA) modified oligonucleotides.

Egli M, Pallan PS, Allerson CR, Prakash TP, Berdeja A, Yu J, Lee S, Watt A, Gaus H, Bhat B, Swayze EE, Seth PP
J Am Chem Soc. 2011 133 (41): 16642-9

PMID: 21919455 · PMCID: PMC3192227 · DOI:10.1021/ja207086x

MeSH Terms (7)

Models, Molecular Molecular Conformation Nucleic Acids Oligonucleotides RNA Stereoisomerism Sugar Alcohols

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