The effect of water disinfection by-products on pregnancy outcomes in two southeastern US communities.

Horton BJ, Luben TJ, Herring AH, Savitz DA, Singer PC, Weinberg HS, Hartmann KE
J Occup Environ Med. 2011 53 (10): 1172-8

PMID: 21915074 · PMCID: PMC3693937 · DOI:10.1097/JOM.0b013e31822b8334

OBJECTIVE - To determine if exposure to disinfection by-products (DBPs) during gestation increases the risk of adverse birth outcomes, specifically term small for gestational age (SGA) birth, preterm birth (PTB), and very PTB (<32 weeks' gestation).

METHODS - We used weekly measurements total trihalomethanes (TTHMs), five haloacetic acids (HAA5), and total organic halides (TOX) collected from two distribution systems to evaluate the associations between DBP concentrations and term SGA, PTB, and very PTB using logistic regression.

RESULTS - We found no associations between DBPs and term-SGA. In the site with higher concentrations of bromine-containing DBPs, we found an association between TOX and PTB; this association was larger, though less precise, for very PTB.

CONCLUSIONS - Our results do not support an association between TTHMs or HAA5 and the birth outcomes investigated, but an association was found between increased TOX and PTB.

MeSH Terms (19)

Adult Birth Weight Female Fetal Growth Retardation Gestational Age Humans Hydrocarbons, Brominated Hydrocarbons, Chlorinated Infant, Newborn Logistic Models Odds Ratio Pregnancy Pregnancy Outcome Premature Birth Southeastern United States Trihalomethanes Water Purification Water Supply Young Adult

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