Design, synthesis, and characterization of nucleic-acid-functionalized gold surfaces for biomarker detection.

Adams NM, Jackson SR, Haselton FR, Wright DW
Langmuir. 2012 28 (2): 1068-82

PMID: 21905721 · PMCID: PMC4211628 · DOI:10.1021/la2028862

Nucleic-acid-functionalized gold surfaces have been used extensively for the development of biological sensors. The development of an effective biomarker detection assay requires careful design, synthesis, and characterization of probe components. In this Feature Article, we describe fundamental probe development constraints and provide a critical appraisal of the current methodologies and applications in the field. We discuss critical issues and obstacles that impede the sensitivity and reliability of the sensors to underscore the challenges that must be met to advance the field of biomarker detection.

© 2011 American Chemical Society

MeSH Terms (9)

Biomarkers Cell Line DNA Barcoding, Taxonomic Gold Humans Metal Nanoparticles Microscopy, Fluorescence Nucleic Acids Surface Properties

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