The novel chemical entity YTR107 inhibits recruitment of nucleophosmin to sites of DNA damage, suppressing repair of DNA double-strand breaks and enhancing radiosensitization.

Sekhar KR, Reddy YT, Reddy PN, Crooks PA, Venkateswaran A, McDonald WH, Geng L, Sasi S, Van Der Waal RP, Roti JL, Salleng KJ, Rachakonda G, Freeman ML
Clin Cancer Res. 2011 17 (20): 6490-9

PMID: 21878537 · PMCID: PMC3195947 · DOI:10.1158/1078-0432.CCR-11-1054

MeSH Terms (18)

Animals Barbiturates Cell Line, Tumor DNA Breaks, Double-Stranded DNA Damage DNA Repair Humans Indoles Mice Mice, Nude Molecular Chaperones Molecular Targeted Therapy Neoplasms Nuclear Proteins Nucleophosmin Radiation-Sensitizing Agents Radiation Tolerance Random Allocation

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