Prediction of hepatocellular carcinoma development by plasma ADAMTS13 in chronic hepatitis B and C.

Ikeda H, Tateishi R, Enooku K, Yoshida H, Nakagawa H, Masuzaki R, Kondo Y, Goto T, Shiina S, Kume Y, Tomiya T, Inoue Y, Nishikawa T, Ohtomo N, Tanoue Y, Ono T, Koike K, Yatomi Y
Cancer Epidemiol Biomarkers Prev. 2011 20 (10): 2204-11

PMID: 21876190 · DOI:10.1158/1055-9965.EPI-11-0464

BACKGROUND - Chronic liver injury evokes a wound healing response, promoting fibrosis and finally hepatocellular carcinoma (HCC), in which hepatic stellate cells play an important role. Although a blood marker of hepatic stellate cells is not known, those cells importantly contribute to the regulation of plasma a disintegrin-like and metalloproteinase with thrombospondin type-1 motifs 13 (ADAMTS13) activity, a defect of which causes thrombotic thrombocytopenic purpura.

METHODS - Plasma ADAMTS13 was evaluated in chronic hepatitis B or C patients with or without HCC.

RESULTS - Plasma ADAMTS13 activity significantly correlated with serum aspartate aminotransferase and alanine aminotransferase, liver stiffness value, and aspartate aminotransferase-to-platelet ratio index, irrespective of the presence of HCC, suggesting that it may reflect hepatocellular damage and subsequent wound healing and fibrosis as a result of hepatic stellate cell action. During the three-year follow-up period for patients without HCC, it developed in 10 among 81 patients. Plasma ADAMTS13 activity was significantly higher in patients with HCC development than in those without and was a significant risk for HCC development by univariate and multivariate analyses. Furthermore, during the one-year follow-up period for patients with HCC treated with radiofrequency ablation, HCC recurred in 55 among 107 patients. Plasma ADAMTS13 activity or antigen level was significantly higher in patients with HCC recurrence than in those without and was retained as a significant risk for HCC recurrence by multivariate analysis.

CONCLUSIONS - Higher plasma ADAMTS13 activity and antigen level was a risk of HCC development in chronic liver disease.

IMPACT - Plasma ADAMTS13 as a potential marker of hepatic stellate cells may be useful in the prediction of hepatocarcinogenesis.

©2011 AACR

MeSH Terms (23)

ADAM Proteins ADAMTS13 Protein Aged Alanine Transaminase Aspartate Aminotransferases Biomarkers, Tumor Blood Proteins Carcinoma, Hepatocellular Case-Control Studies Enzyme-Linked Immunosorbent Assay Female Follow-Up Studies Hepacivirus Hepatic Stellate Cells Hepatitis B, Chronic Hepatitis B virus Hepatitis C, Chronic Humans Liver Neoplasms Male Middle Aged Neoplasm Recurrence, Local Prognosis

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